Author

Quang M. Trinh

Ontario Institute for Cancer ResearchORCID 0000-0002-3602-2290Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Lincoln David SteiniD· 2 shared Adam WrightiD· 1 shared Aditi Soni· 1 shared Andrey A. BobkoviD· 1 shared Anindya BagchiiD· 1 shared Aniruddha Deshpande· 1 shared Ashutosh Tiwari· 1 shared Badrinath R. KonetyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Lincoln David SteinORCID

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2 papers

Recent·Most cited

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

Ashutosh Tiwari, Utkarsha Paithane, Jordan Friedlein, Kojiro Tashiro, Olivier Saulnier, Karina Barbosa, Quang M. Trinh, Bryan Hall, Shrawantee Saha, Aditi Soni, Takuma Nakashima, Andrey A. Bobkov, Lynn Miya Fujimoto, Rabi Murad, Svetlana Rajkumar Maurya, , Anindya Bagchi

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

bioRxiv · Feb 17, 2025 · PreprintCancer Biology

Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes

Marija Orlic-Milacic, Karen Rothfels, Lisa R. Matthews, Adam Wright, Bijay Jassal, Veronica Shamovsky, Quang M. Trinh, Marc E. Gillespie, Cristoffer Sevilla, Krishna Kumar Tiwari, Eliot Ragueneau, Chuqiao Gong, Ralf Stephan, Bruce May, Robin Haw, , Guanming Wu

The paper annotates disease variants in the context of biological pathways to infer molecular phenotypes and model variant impacts.

Database · Jan 1, 2024Peer-reviewedSystems Biology