The filopodial scaffold polyphosphate dictates cell adhesion-versus-invasion decisions
Akash Rai, Aanchal Jain, Hannah Zunker, Bonje N. Obua, Harshita Ramchandani, Jian Guan, Akter Mousumi, Yongkang Xi, Amanda Erwin, Pavithra Mahadevan, Bryndon J. Oleson, Adrian BJ Bardwell, Jaclyn Shoudis, Jiage Song, Megha Suresh, , Ursula Jakob
This study identifies polyphosphate as a structural component of filopodia that regulates cell adhesion and invasion, with implications for tumor suppression.
bioRxiv · Sep 3, 2026 · PreprintCell Biology