Megha Suresh

The filopodial scaffold polyphosphate dictates cell adhesion-versus-invasion decisions

This study identifies polyphosphate as a structural component of filopodia that regulates cell adhesion and invasion, with implications for tumor suppression.

A genome-wide CRISPR Screening identifies targets that drive Tolerogenic Dendritic Cells

This study uses CRISPR screening to identify molecular targets that drive the function of tolerogenic dendritic cells, revealing CD86 and UBE2L6 as key regulators of immune tolerance.

A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor

The paper investigates the functional role of the unstructured C-terminal domain (CTD) of CtBP proteins by comparing isoforms with and without the CTD in Drosophila, showing context-dependent repression activity.

In vitro model of inflammatory, hypoxia, and cancer stem cell signaling in pancreatic cancer using heterocellular 3-dimensional spheroids

This study develops 3D co-culture spheroid models of pancreatic cancer to mimic tumor microenvironment interactions and assess inflammatory, hypoxia, and cancer stem cell markers.