Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion
Adrian W. Briggs, Stephen J. Goldfless, Sonia Timberlake, Brian J. Belmont, Christopher R. Clouser, David Koppstein, Devin Sok, Jason Vander A. Heiden, Manu V. Tamminen, Steven H. Kleinstein, Dennis R. Burton, George M. Church, Francois Vigneault
The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.
bioRxiv · May 5, 2017 · PreprintImmunology