Author

Stephen J. Goldfless

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Francois Vigneault· 3 shared Adrian W. BriggsiD· 2 shared David Koppstein· 2 shared George M. Church· 2 shared Gurinder S. AtwaliD· 2 shared Jason A. CarteriD· 2 shared Kristina Grigaityte· 2 shared Adrian W. Briggs· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

Francois Vigneault

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Author profile →

3 papers

Recent·Most cited

T-cell receptor αβ chain pairing is associated with CD4+ and CD8+ lineage specification

Jason A. Carter, Jonathan B. Preall, Kristina Grigaityte, Stephen J. Goldfless, Adrian W. Briggs, Francois Vigneault, Gurinder S. Atwal

The paper analyzes TCR {beta} chain pairing in human T-cells to determine its role in CD4+ and CD8+ lineage specification, finding that {beta} chain pairs are more informative than individual chains for lineage prediction.

bioRxiv · Apr 3, 2018 · PreprintImmunology

Single-cell sequencing reveals αβ chain pairing shapes the T cell repertoire

Kristina Grigaityte, Jason A. Carter, Stephen J. Goldfless, Eric W. Jeffery, Ronald J. Hause, Yue Jiang, David Koppstein, Adrian W. Briggs, George M. Church, Francois Vigneault, Gurinder S. Atwal

This study uses single-cell sequencing to analyze T cell receptor pairing, finding non-random β chain associations and public clone sharing, which reduce T cell repertoire diversity.

bioRxiv · Nov 2, 2017 · PreprintImmunology

Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

Adrian W. Briggs, Stephen J. Goldfless, Sonia Timberlake, Brian J. Belmont, Christopher R. Clouser, David Koppstein, Devin Sok, Jason Vander A. Heiden, Manu V. Tamminen, Steven H. Kleinstein, Dennis R. Burton, George M. Church, Francois Vigneault

The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.

bioRxiv · May 5, 2017 · PreprintImmunology