Author

David Koppstein

Primary ORCID profile (0000-0002-8618-7237 · 6 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

David KoppsteiniD6 papers · German Cancer Research Center

Biology Disciplines

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Francois Vigneault· 2 shared George M. Church· 2 shared Stephen J. Goldfless· 2 shared Adrian W. BriggsiD· 1 shared Adrian W. Briggs· 1 shared Brian J. Belmont· 1 shared Christopher R. Clouser· 1 shared Dennis R. BurtoniD· 1 shared

Activity by Year

2017-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Francois Vigneault

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2 papers

Recent·Most cited

Single-cell sequencing reveals αβ chain pairing shapes the T cell repertoire

Kristina Grigaityte, Jason A. Carter, Stephen J. Goldfless, Eric W. Jeffery, Ronald J. Hause, Yue Jiang, David Koppstein, Adrian W. Briggs, George M. Church, Francois Vigneault, Gurinder S. Atwal

This study uses single-cell sequencing to analyze T cell receptor pairing, finding non-random β chain associations and public clone sharing, which reduce T cell repertoire diversity.

bioRxiv · Nov 2, 2017 · PreprintImmunology

Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

Adrian W. Briggs, Stephen J. Goldfless, Sonia Timberlake, Brian J. Belmont, Christopher R. Clouser, David Koppstein, Devin Sok, Jason Vander A. Heiden, Manu V. Tamminen, Steven H. Kleinstein, Dennis R. Burton, George M. Church, Francois Vigneault

The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.

bioRxiv · May 5, 2017 · PreprintImmunology