ImmunologybioRxiv
Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3-/- mice
Felix D. Weiss, Yubell Alvarez, Farhad Shakeri…·Felix Meissner
The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.
DOI 10.1038/s41418-024-01379-2