Eicke Latz

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study shows that local albumin excess in the vagina exacerbates Candida albicans-induced inflammasome activation, contributing to hyperinflammation in vulvovaginal candidiasis.

This study shows that NLRP3 inflammasome activation drives JAK2V617F mutant myeloproliferative neoplasms by promoting inflammation, platelet production, and fibrosis, and that its inhibition can reverse disease features.

This study investigates the role of NLRP3 inhibition in reducing neuroinflammation and improving behavioral recovery after traumatic brain injury.

This study shows that ASC sustains neuroinflammation and contributes to cognitive deficits after mild closed-head injury.

The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.

The paper introduces NIS-Seq, a method for genome-scale optical perturbation screening in any nucleus-containing cell type, and demonstrates its application in identifying inflammation-related pathway components.

NULISA is a proteomic platform with attomolar sensitivity and high multiplexing, enabling detection of low-abundance proteins in liquid biopsies.

This study investigates how IL4 signalling and NCOR2 regulate the reprogramming of human monocytes into dendritic cells and macrophages, revealing distinct transcriptional and functional profiles based on cytokine exposure timing.