Felix Meissner

This study shows that different stress types cause distinct plasma proteomic and metabolic responses in humans, with physical stress having the strongest effect.

The paper identifies MTAP deficiency as a biomarker in lung neuroendocrine neoplasms, distinguishing carcinoids from SCLC and LCNEC, and shows it is not caused by 9p21 deletion or promoter hypermethylation.

This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

This study shows that VPS18 mutations disrupt neutrophil maturation by impairing vesicle dynamics and autophagy, leading to neutropenia and recurrent infections.

This study shows that yolk sac-derived Kupffer cells regulate neonatal hepatocyte metabolism via Igf1 signaling, essential for glycogen storage and TCA cycle function.

This study investigates the role of NLRP3 inhibition in reducing neuroinflammation and improving behavioral recovery after traumatic brain injury.

This study identifies miR-196a-5p and miR-342-3p as exomiRs released during exercise that mediate crosstalk between skeletal muscle and thermogenic adipose tissue.

This study shows that cytohesin-2 is essential for mouse survival and regulates Golgi volume and function through in vivo and in vitro analyses.

The paper shows that centrosomes in non-dividing cells can fracture under mechanical stress during cell navigation, and Dyrk3 prevents this fracturing to maintain cellular function.

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.

The paper identifies retention of 129S genome in Nlrp3-/- mice causing NLRP1 hypersensitivity and transcriptional changes, and introduces a conditional Nlrp3 allele to resolve phenotypes.

The paper introduces a method to identify covalent modifications and protein interactions regulating immune signaling complex composition and function in monocytes.

This study identifies TDP-25 inclusions as sequestering proteasomes, leading to proteostasis impairment in ALS/FTD.

This study investigates how CD81 senses cholesterol and how this affects its function as a hepatitis C virus receptor, finding that cholesterol binding regulates CD81's conformation and receptor activity.