Author

Adriana Saba

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dennis J. SelkoeiD· 3 shared Hyun‐Sik YangiD· 3 shared Jasmeer P. ChhatwaliD· 3 shared Lei LiuiD· 3 shared Amy Li· 2 shared Jean‐Pierre BellieriD· 2 shared Alan Y. Chen· 1 shared Andrea M. Román VieraiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Dennis J. SelkoeORCID

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Author profile →

3 papers

Recent·Most cited

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean‐Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L. Hennessey, Samadhi P. Wijethunga, Elif Lara Okyay, Michael B. Miller, Hyun‐Sik Yang, Dennis J. Selkoe, Jasmeer P. Chhatwal

The paper develops and validates CNS-tau-specific monoclonal antibodies for use in neuropathology and plasma biomarker assays across Alzheimer's disease and primary tauopathies.

bioRxiv · Sep 14, 2025 · PreprintNeuroscience

The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

Lei Liu, Stephanie A. Schultz, Adriana Saba, Hyun‐Sik Yang, Amy Li, Dennis J. Selkoe, Jasmeer P. Chhatwal

The paper assesses the pathogenicity of PSEN2 variants by comparing Aβ production and homology to PSEN1 variants, finding correlations with age at symptom onset.

Alzheimer s & Dementia · Nov 19, 2024Peer-reviewedNeuroscience

Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Jean‐Pierre Bellier, Andrea M. Román Viera, Caitlyn Christiano, Juliana A. U. Anzai, Stephanie Moreno, Emily C. Campbell, Lucas Godwin, Amy Li, Alan Y. Chen, Sarah Alam, Adriana Saba, Han bin Yoo, Hyun‐Sik Yang, Jasmeer P. Chhatwal, Dennis J. Selkoe, Lei Liu

This study identifies fibrinogen as a plasma protein binding partner for lecanemab biosimilar, suggesting it may affect drug half-life and free antibody levels in Alzheimer's disease therapy.

bioRxiv · May 1, 2024 · PreprintNeuroscience