Integrating pharmacogenomics data-driven prediction with bulk and single-cell RNAseq to demonstrate the efficacy of an NAMPT inhibitor against aggressive, taxane-resistant, and stem-like cells in lethal prostate cancer
Suman Mazumder, Taraswi Mitra Ghosh, Ujjal Kumar Mukherjee, Sayak Chakravarti, Farshad Amiri, Farnaz Hemmati, Panagiotis Mistriotis, Isra A. Elhussin, Ahmad-Bin Salam, Windy Marie Dean-Colomb, Feng Li, Clayton Clopton Yates, Robert D. Arnold, Amit Mitra
The paper uses scRNAseq and pharmacogenomics to identify FK866 as a potential drug for aggressive prostate cancer, showing its efficacy against drug-resistant and stem-like cells.
bioRxiv · Jul 20, 2022 · PreprintMolecular Biology