Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment
Ahmed Bulldan, Min Jing Zheng, Christian Meyners, Patrick L. Purder, Johannes Krieger, Johannes Kilian Dreizler, Thomas M. Geiger, Maximilian L. Repity, Marte Høen Lein, Ingrid Quist-Løkken, Noel Tewes, Martin P. Schwalm, Sarah Schlesiger, S. Moniot, Stefan Knapp, , Felix Hausch
This study develops heterobifunctional protein binders that selectively kill specific cell types by leveraging the abundance of FKBP12, demonstrating enhanced efficacy through cellular enrichment.
bioRxiv · May 16, 2025 · PreprintBiochemistry