Felix Hausch

This study shows that inhibiting FKBP51 with SAFit2 prevents social deficits caused by early life adversity in mice.

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

The paper identifies a novel multi-cochaperone complex involving GR, p23, FKBP51, and Hsp90 using site-specific in-cell photocrosslinking, revealing functional differences between FKBP51 and FKBP52.

This study develops heterobifunctional protein binders that selectively kill specific cell types by leveraging the abundance of FKBP12, demonstrating enhanced efficacy through cellular enrichment.

This study identifies and characterizes the first inhibitors of the B0AT2/SLC6A15 amino acid transporter, showing potent and selective inhibition with effects on neurite outgrowth.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

This study investigates the role of FKBP5 and the HPA axis in alcohol memory reconsolidation, finding that FKBP51 inhibition affects cognitive flexibility but HPA axis manipulations do not impact reconsolidation.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.