Alexander Loewer

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

This study investigates how different DNA damage stimuli regulate p53 target gene promoter activity through stochastic gene expression, revealing stimulus-specific activation and deactivation rates.

This study develops heterobifunctional protein binders that selectively kill specific cell types by leveraging the abundance of FKBP12, demonstrating enhanced efficacy through cellular enrichment.

The paper links TGFβ signaling, gene expression, and cellular fate decisions in mammary epithelial cells, identifying transcriptional regulators that ensure specific responses at high TGFβ doses.

The paper investigates how p53-mediated transcriptional responses to DNA damage are modulated by stochastic bursting frequency, identifying distinct gene expression archetypes.