Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer
Ahmed Mahmoud, Philip H. Choi, Christine Sukhwa, Jura Pintar, Henry S. Walch, Nan Zhao, Jonathan Bermeo, Sebastian K. Chung, Manisha S. Raghavan, Samhita Bapat, Qingwen Jiang, Georgios Karagkounis, Julia Meredith, Michael Giarrizzo, Canan Fırat, , Karuna Ganesh
The paper develops patient-derived organoids and mouse models of appendiceal cancer to identify phenotypic changes and drug targets in peritoneal metastasis.
bioRxiv · Feb 17, 2025 · PreprintCancer Biology