Karuna Ganesh

Hierarchical classification of immune cell transcriptomes at population-scale

The paper introduces Suco and Compocyte to classify immune cells from 3,965 patients, identifying new macrophage and monocyte states and T cell memory erosion in metastases.

Development of antibody-drug conjugates targeting L1CAM to treat metastatic cancer

This paper develops antibody-drug conjugates targeting L1CAM to treat metastatic cancer, showing potent tumor control and extended survival in mouse models.

Reconstructing physiological oxygen gradients reveals the role of hypoxia in colon epithelial organization

The paper quantifies oxygen gradients in the intestine and recreates them ex vivo to study hypoxia's role in epithelial organization.

Inferring cancer type-specific patterns of metastatic spread using Metient

Metient infers cancer type-specific metastatic spread patterns using gradient-based optimization, revealing new insights into metastasis mechanisms and treatment strategies.

Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer

The paper identifies two distinct regulatory T cell subsets in colorectal cancer with opposing roles in tumor growth and prognosis.

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer

The paper develops patient-derived organoids and mouse models of appendiceal cancer to identify phenotypic changes and drug targets in peritoneal metastasis.