Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways
Lavanya Choppavarapu, Kun Fang, Tianxiang Liu, Aigbe Gregory Ohihoin, Victor X. Jin
The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.
Cell Reports · Mar 18, 2025Peer-reviewedCancer Biology