Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment
Masayoshi Nagai, Robert S. Porter, Maxwell Miyasato, Aijia Wang, Cecilia M Gavilan, Elizabeth D. Hughes, Michael C. Wu, Thomas L. Saunders, Shigeki Iwase
The paper shows that PHF21A microexon expression precedes LSD1 microexon expression during neurodevelopment, leading to stepwise deactivation of the LSD1-PHF21A complex and unique gene-regulatory roles in neurons.
Journal of Biological Chemistry · Oct 10, 2024Peer-reviewedBiochemistry