Author

Michael C. Wu

ORCID 0000-0002-3829-8039Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Robert S. PorteriD· 2 shared Shigeki IwaseiD· 2 shared Aijia Wang· 1 shared Brynne RainesiD· 1 shared Catherine E. KeeganiD· 1 shared Cecilia M Gavilan· 1 shared Christina N. VallianatosiD· 1 shared Elizabeth D. Hughes· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Robert S. PorterORCID

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2 papers

Recent·Most cited

Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment

Masayoshi Nagai, Robert S. Porter, Maxwell Miyasato, Aijia Wang, Cecilia M Gavilan, Elizabeth D. Hughes, Michael C. Wu, Thomas L. Saunders, Shigeki Iwase

The paper shows that PHF21A microexon expression precedes LSD1 microexon expression during neurodevelopment, leading to stepwise deactivation of the LSD1-PHF21A complex and unique gene-regulatory roles in neurons.

Journal of Biological Chemistry · Oct 10, 2024Peer-reviewedBiochemistry

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

Christina N. Vallianatos, Brynne Raines, Robert S. Porter, Katherine M. Bonefas, Michael C. Wu, Patricia Marie Garay, Katie M. Collette, Young Ah Seo, Yali Dou, Catherine E. Keegan, Natalie Celia Tronson, Shigeki Iwase

This study shows that KMT2A and KDM5C, which have opposing enzymatic activities, work together to regulate neuronal structure, behavior, and H3K4 methylation, with their combined loss reversing some phenotypes.

Communications Biology · Jun 1, 2020Peer-reviewedGenetics