Human chaperones untangle fibrils of the Alzheimer protein Tau
Luca Ferrari, Willie J.C. Geerts, Marloes van Wezel, Renate Kos, Aikaterini Konstantoulea, Laura S. van Bezouwen, Friedrich G. Förster, Stefan G.D. Rüdiger
This study shows human Hsp70 chaperones can dissolve Tau fibrils, while bacterial Hsp70 systems cannot, suggesting evolutionary adaptation for fibril disaggregation and potential therapeutic applications for Alzheimer's.
bioRxiv · Sep 26, 2018 · PreprintBiochemistry