Luca Ferrari

The paper investigates how TAX1BP1 recruits the autophagy machinery to switch from cargo collection to sequestration in aggrephagy.

This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.

This study shows human Hsp70 chaperones can dissolve Tau fibrils, while bacterial Hsp70 systems cannot, suggesting evolutionary adaptation for fibril disaggregation and potential therapeutic applications for Alzheimer's.