Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion
Ankit Srivastava, Tomas Bencomo, Chaw‐Ning Lee, Angela Mah, Jasmine M. Garcia, Lek Wei Seow, Isoline M. Donohue, Aiko J. Tan, Audrey D. Nguyen, Tiffany Jiang, Saurabh Gombar, Lilian Phu, Pankaj Dwivedi, Christopher M. Rose, Ryanne A. Brown, Carolyn S. Lee
This study identifies mast cell-derived histamine as a regulator of perineural invasion in epithelial cancers, showing that H1-antihistamines improve survival and immunotherapy response.
bioRxiv · Jun 23, 2025 · PreprintCancer Biology