Christopher M. Rose

Cell-Type-Specific Surfaceome Profiling of 100-500 Isolated Cells using a Droplet-Based Magnetic Affinity Purification System

The paper develops nanoMAPS, a droplet-based magnetic affinity purification system for surfaceome profiling of 100-500 cells, improving recovery and reducing non-specific absorption.

Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

This study identifies six microglial transcriptional profiles linked to specific morphological phenotypes and shows AD risk genes disrupt morpho-transcriptomic coupling and phagocytic capacity.

Architecture and Function of Holocentric CENP-A-Independent Kinetochores

The paper determines the cryo-EM structure of the holocentric CCAN from Bombyx mori, revealing a self-contained dimer that forms a point-centromere-like architecture and incorporates novel Centromeric Subunit proteins.

Real-time artificial intelligence prediction of peptide characteristics and MSFragger search improves multiplexed quantification of non-canonical HLA presented peptides in clear cell renal cell carcinoma.

The paper introduces MIRA-MS, a real-time AI-guided acquisition method that improves quantification of non-canonical HLA peptides in clear cell renal cell carcinoma.

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer's Disease pathology

This study uses direct RNA sequencing to analyze epitranscriptomic changes in brain cells, revealing m6A modification patterns linked to Alzheimer's disease progression.

Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling

This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.

A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917

This study shows that the bile acid lithocholic acid promotes biofilm formation by the probiotic Escherichia coli Nissle 1917, enhancing its ability to compete with pathogens.

Nova: A library for rapid development of mass spectrometry software applications

Nova is a C# library for handling mass spectrometry data, offering native support and extensibility for real-time analysis and instrument control applications.

Epithelial tumor cells utilize mast cell-derived histamine to regulate perineural invasion

This study identifies mast cell-derived histamine as a regulator of perineural invasion in epithelial cancers, showing that H1-antihistamines improve survival and immunotherapy response.

Offset mass carrier proteome improves quantification of multiplexed single cell proteomics

The paper introduces toma-scpMS, a method that improves quantification in multiplexed single cell proteomics by separating carrier and single cell proteomes during mass spectrometry.

diaPASEF analysis for HLA-I peptides enables quantification of common cancer neoantigens

This study evaluates diaPASEF for high-sensitivity identification and quantification of HLA-I peptides, demonstrating improved detection of neoantigens in cancer models.