Inflammasome Activation and IL-1β Release in Alveolar Macrophages Infected with Pseudomonas aeruginosa is Reduced in Hypoxia
Alexander W. Rapp, Aurora Golden, Arianna D. Reuven, Jay Goddard, Emily Ann McClure, Aimee Wilson, Chloe Young, Caitlin Murphy, Taalia-Lindsay Morgan, Andrew J. Olive, Deborah Hogan, Joshua J. Obar, Benjamin D. Ross, James B. Bliska
This study shows that Pseudomonas aeruginosa CF isolate DH1137 reduces inflammasome activation and IL-1β release in alveolar macrophages under hypoxia, potentially aiding immune evasion in cystic fibrosis.
bioRxiv · Oct 28, 2026 · PreprintImmunology