Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility
Lisa Blackmer‐Raynolds, Lyndsey D. Lipson, Anna Kozlov, Aimee Yang, Emily J. Hill, Maureen McGuirk Sampson, Adam M. Hamilton, Isabel Fraccaroli, Sean D. Kelly, Pankaj Chopra, Jianjun Chang, Steven A. Sloan, Timothy Robert Sampson
This study shows that gut microbes influence the transcriptional states of brain cell types and affect neurodegenerative disease susceptibility, with E. coli specifically worsening Alzheimer's disease outcomes in mice.
Cell Systems · Feb 1, 2026Peer-reviewedNeuroscience