Emily J. Hill

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signatures

This study develops human spinal cord organoids and assembloids to model oligodendrocyte development and disease states, showing they recapitulate developmental signatures and cytokine-induced dysfunction seen in multiple sclerosis.

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

This study shows that gut microbes influence the transcriptional states of brain cell types and affect neurodegenerative disease susceptibility, with E. coli specifically worsening Alzheimer's disease outcomes in mice.