Maureen McGuirk Sampson

This paper identifies a novel mechanism by which manganese disrupts mitochondrial transcriptome processing, leading to dsRNA accumulation and neuroinflammation through MDA5 activation.

This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.

This study shows human astrocytes can present antigens via MHCII after chronic cytokine exposure, revealing their potential as antigen-presenting cells.

This study shows that gut microbes influence the transcriptional states of brain cell types and affect neurodegenerative disease susceptibility, with E. coli specifically worsening Alzheimer's disease outcomes in mice.

This study investigates the effects of Zika virus infection on infant brain development using single-cell transcriptomics and other methods, identifying disrupted pathways and behavioral changes.

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

The paper develops a method to tag endogenous GPCRs in Drosophila for localization studies and uses it to investigate receptor distribution and function in neural circuits.

This study creates dSERT mutants in Drosophila to investigate serotonin's role in sleep, feeding, and courtship, finding increased sleep and behavioral defects.

This study identifies serotonin receptor expression in Drosophila visual neurons and shows serotonin modulates visual processing through calcium signaling changes.