Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer
Ariane Schaub-Clerigué, Ivana Heřmanová, Ainara Pintor-Rial, Mariia Sydorenko, Lorea Valcárcel-Jiménez, Alice Macchia, Benoit Louis Philippe Lectez, Saioa Garcia‐Longarte, Maider Fagoaga-Eugui, Ianire Astobiza, Natalia Martín-Martín, Amaia Zabala‐Letona, Mikel Pujana-Vaquerizo, Félix Royo, Mikel Azkargorta, , Verónica Torrano
This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.
Cell Death and Disease · Apr 23, 2025Peer-reviewedCancer Biology