Amaia Zabala‐Letona

This study analyzes PTEN-deficient prostate tumors to reveal stromal reprogramming and senescent paracrine communication through transcriptional network analysis and single-cell RNA-Seq.

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

The paper develops and validates a method to measure polyamine levels in cultured cells, showing varying sensitivity for different polyamines.

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.