Cell-stereotyped DNA repair outcomes are widespread during genome editing
Moritz F. Schlapansky, Markus Schröder, António J. Santinha, Tanja Rothgangl, Eleonora I. Ioannidi, Grégoire Cullot, Bohdan Lewków, Germán Camargo Ortega, Nouraiz Ahmed, Dominic Mailänder, Louisa Selbert, Simon Lam, Aitana Egea, Jiyung J. Shin, Matteo Bordi, , Jacob E. Corn
The paper develops scOUT-seq to profile DNA repair outcomes in single cells and finds that repair outcomes vary significantly across cell types and subtypes.
bioRxiv · Oct 23, 2025 · PreprintGenomics