Ana Gvozdenovic

The paper identifies differences in liver and lung metastatic niches in breast cancer, showing liver promotes metastasis while lungs inhibit it, and highlights BMP2-producing endothelial cells in the liver as key players.

The paper improves the activity of compact RNA-guided nucleases in mammalian cells through directed evolution, resulting in variants with higher editing efficiency and reduced off-target effects.

The paper develops scOUT-seq to profile DNA repair outcomes in single cells and finds that repair outcomes vary significantly across cell types and subtypes.

The paper identifies CCAR1 as a splicing fidelity factor that regulates alternative splicing of FANCA and other genes, impacting DNA repair processes.