Simon Lam

The paper identifies MAEA as a critical regulator of DNA repair and replication, with loss of function causing developmental delay and neurodevelopmental deficits.

The paper develops scOUT-seq to profile DNA repair outcomes in single cells and finds that repair outcomes vary significantly across cell types and subtypes.

This study shows WEE1 inhibitors work better with mRNA translation defects by activating GCN2, and suggests ways to reduce off-target effects.

This study shows that USP37 prevents premature TRAIP-mediated disassembly of stalled replisomes, maintaining genome stability under replication stress.

The paper introduces Exorcise, a tool to reannotate CRISPR libraries to user-defined genomes, improving targeting accuracy and reducing bias in screens.

This study shows that dinoflagellates can acquire and utilize haptophyte-derived plastids, demonstrating that complex plastids can be transferred between hosts.

This study identifies immunomodulatory peptides deregulated in breast cancer using single-cell and spatial transcriptomics, and proposes drugs to modulate their expression.

This study identifies retinoids and sex hormone dysregulation as ageing-related features in Alzheimer's and Parkinson's disease subclasses using transcriptomic and metabolic analyses.