Dietary salt promotes cognitive impairment through tau phosphorylation
Giuseppe Faraco, Karin Hochrainer, Steven G. Segarra, Samantha M Schaeffer, Monica M. Santisteban, Ajay Menon, Hong Jiang, David M. Holtzman, Josef Anrather, Costantino Iadecola
This study shows that a high-salt diet causes cognitive impairment in mice through tau hyperphosphorylation, which is prevented by restoring nitric oxide production.
Nature · Oct 23, 2019Peer-reviewedNeuroscience