Author

Samantha M Schaeffer

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 3

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Costantino IadecolaiD· 3 shared Giuseppe FaracoiD· 3 shared Josef AnratheriD· 3 shared Monica M. SantistebaniD· 3 shared Gianfranco Racchumi· 2 shared Laibaik ParkiD· 2 shared Ajay Menon· 1 shared Anthony G. PacholkoiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Costantino IadecolaORCID

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3 papers

Recent·Most cited

Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution

Anthony G. Pacholko, Samantha M Schaeffer, Monica M. Santisteban, Sung Ji Ahn, Gianfranco Racchumi, Gang Wang, Laibaik Park, Giuseppe Faraco, Josef Anrather, Costantino Iadecola

This study uses scRNA-seq in a mouse hypertension model to identify early molecular changes in brain cells linked to neurovascular dysfunction and cognitive impairment.

bioRxiv · Apr 14, 2025 · PreprintNeuroscience

Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension

Monica M. Santisteban, Samantha M Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa Sobanko, Rose K. Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola

This study identifies meningeal IL-17-producing T cells as a key driver of cognitive impairment in hypertension, showing their role in activating brain macrophages and suggesting therapeutic targets.

bioRxiv · Sep 5, 2022 · PreprintNeuroscience

Dietary salt promotes cognitive impairment through tau phosphorylation

Giuseppe Faraco, Karin Hochrainer, Steven G. Segarra, Samantha M Schaeffer, Monica M. Santisteban, Ajay Menon, Hong Jiang, David M. Holtzman, Josef Anrather, Costantino Iadecola

This study shows that a high-salt diet causes cognitive impairment in mice through tau hyperphosphorylation, which is prevented by restoring nitric oxide production.

Nature · Oct 23, 2019Peer-reviewedNeuroscience