PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) Medulloblastoma
Devendra Kumar, Ajay Sharma, Amit K. Dash, Ranjana Kumari Kanchan, Ling Ding, Yashpal Singh Chhonker, Sushil Kumar Shakyawar, Chittibabu Guda, Ganesh R Naik, Daryl J. Murry, Sutapa Ray, Hamid Band, Donald W. Coulter, Nagendra K. Chaturvedi
This study identifies PRMT5 as an epigenetic regulator of MYC transcription and oncogenic programs in Group 3 medulloblastoma, showing that its inhibition suppresses tumor growth and prolongs survival in mouse models.
bioRxiv · Apr 13, 2026 · PreprintCancer Biology