Ling Ding

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) Medulloblastoma

This study identifies PRMT5 as an epigenetic regulator of MYC transcription and oncogenic programs in Group 3 medulloblastoma, showing that its inhibition suppresses tumor growth and prolongs survival in mouse models.

Structure-Activity Mapping of Intraperitoneal mRNA-LNPs: Decoupling Tumor and Liver Biodistribution in Pancreatic Cancer

This study identifies mRNA-LNP formulation features that enhance tumor delivery and reduce liver accumulation in pancreatic cancer.

A gentle palette of plasma membrane dyes

This paper introduces PK Mem dyes for time-lapse fluorescence imaging, showing reduced phototoxicity and improved photostability for live and fixed cell imaging.

Inhalable Perfluorocarbon RNA Nanocapsules Bypass Immune Clearance While Targeting Lung Epithelial and Lung Tumor Cells

This paper develops inhalable perfluorocarbon RNA nanocapsules that bypass immune clearance and target lung cells, showing efficient delivery and therapeutic effects in a lung metastasis model.

Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis

This study identifies Palmdelphin as a marker of colorectal cancer stem cells that promotes tumorigenesis by facilitating R-spondin2 secretion and Wnt signaling activation.