Author

Ajeet Mandal

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Assay:bulk RNA-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Pavan Kumar AuluckiD· 4 shared Kimberley J. BillingsleyiD· 3 shared Mark CooksoniD· 3 shared Melissa MeredithiD· 3 shared Mike A. NallsiD· 3 shared Miten JainiD· 3 shared Stefano MarencoiD· 3 shared Xylena ReediD· 3 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Pavan Kumar AuluckORCID

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Author profile →

4 papers

Recent·Most cited

Haplotype-Resolved DNA Methylation at the APOE Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer's Disease Risk

Rylee M. Genner, Melissa Meredith, Kensuke Daida, Abraham Moller, Cory A. Weller, Alexis Ayuketah, Pilar Álvarez Jerez, Stuart Akeson, Laksh Malik, Breeana Baker, Cedric Kouam, Kimberly Paquette, Adam Catching, Sarah Bromberek, Fangle Hu, , Kimberley J. Billingsley

This paper uses long-read sequencing to analyze haplotype-resolved DNA methylation at the APOE locus in brain samples, identifying allele-specific methylation patterns linked to Alzheimer's disease risk.

npj Dementia · Jun 19, 2026Peer-reviewedGenomics

Long-Read epigenetic clocks identify improved brain aging predictions

Spencer M. Grant, Sarah J. Eger, Mary B. Makarious, Melissa Meredith, Abraham G Moller, Melissa Grant‐Peters, Amy R. Hicks, Ajeet Mandal, Pavan Kumar Auluck, Andrés Villegas‐Lanau, Bárbara Mejía‐Cupajita, Juliana Acosta‐Uribe, David Fernando Aguillon, Hampton L. Leonard, Nicole Kuznetsov, , Kimberley J. Billingsley

The paper develops epigenetic clocks using long-read DNA methylation data from diverse ancestries, showing improved aging predictions and identifying ancestry-specific aging pathways.

bioRxiv · Sep 30, 2025 · PreprintBioinformatics

Haplotype-Resolved Long-Read Sequencing in Hundreds of Diverse Brains Identifies Structural Variant Impacts on Expression and Allele-Specific Methylation

Melissa Meredith, Kensuke Daida, Abraham Moller, Pilar Álvarez Jerez, Shloka Negi, Laksh Malik, Rylee M. Genner, Xinchang Zheng, Sophia B Gibson, Mira Mastoras, Breeana Baker, Cedric Kouam, Kimberly Paquette, Paige Jarreau, Mary B. Makarious, , Kimberley J. Billingsley

The paper uses long-read sequencing to identify structural variants and their impacts on gene expression and methylation in diverse human brain samples.

bioRxiv · Dec 16, 2024 · PreprintGenomics

Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain

Pengfei Dong, Gabriel E. Hoffman, Pasha Apontes, Jaroslav M. Bendl, Samir Rahman, Michael B. Fernando, Biao Zeng, James M. Vicari, Wen Zhang, Kiran Girdhar, Kayla G. Townsley, Ruth Misir, Andrew J. Chess, Attila Gulyás-Kovács, Bibi S. Kassim, , Panos Roussos

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

Nature Genetics · Sep 26, 2022Peer-reviewedNeuroscience