Samir Rahman

This paper presents a computational drug repurposing framework that identifies FDA-approved drugs for COVID-19 by integrating genetic expression data and EMR data, finding four compounds with protective effects in validation.

The paper profiles gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 developmental timepoints to study cell fate determination and neuropsychiatric disease mechanisms.

This study investigates the 3D genome organization in human brain development, finding differences in compartment and loop domain formation between neurons and glia.

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

The paper identifies regulatory mechanisms for 21 Alzheimer's disease risk loci in human microglia using transcriptome and chromatin accessibility profiling.

The paper identifies acetylated chromatin domains associated with dysfunction in schizophrenia and bipolar disorder by analyzing histone modifications in prefrontal cortex samples.

The paper investigates mRNP organization and shows that mRNA compaction changes with translational state and that mRNAs are not translated in a closed-loop conformation.