Wen Zhang

Integrative genetic and transcriptomic analysis identifies candidate genes and compounds for Fragile X syndrome and autism spectrum disorder

Evolutionary history and microbial cross-feeding shape lifestyle-stratified dominance of Bifidobacterium longum subspecies in infants

The paper analyzes the evolutionary history and microbial interactions of Bifidobacterium longum subspecies in infants, finding that subspecies distribution is shaped by ecological factors and cross-feeding rather than host-specific factors.

Multi-Modal Deep Learning Integrates Spatial Topologies and Sequential Motifs to Identify Class I HDAC Inhibitors as Pan-Cancer Therapeutics

This paper develops a multi-modal deep learning framework to identify Class I HDAC inhibitors as broad-spectrum anti-cancer agents by integrating chemical and transcriptomic data.

Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through Olig1/2 during Mammalian Cortical Gliogenesis and Gliomagenesis

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

MACGA: Multi-scale Adaptive Convolution with Graph Attention for LncRNA-Disease Association Prediction

MACGA predicts lncRNA-disease associations using a graph attention network with multi-scale adaptive convolution, outperforming existing methods in cross-validation and validated by case studies.

Rprot-Vec: A deep learning approach for fast protein structure similarity calculation

Rprot-Vec is a deep learning model that rapidly calculates protein structural similarity and detects homology using only sequences, achieving 65.3% accuracy in homologous protein prediction.

The Role Of Fzd8 For Bone Development And Homeostasis In A Mouse Model Generated By CRISPR/Cas9 Genome Editing

This study generates an Fzd8-knockout mouse model using CRISPR/Cas9 to investigate its role in bone development and homeostasis, finding altered osteoclast and osteoblast activity and potential links to osteoporosis.

Intra-hypothalamic circuit orchestrates β-endorphin release following coital ejaculation in male mice

The paper identifies a hypothalamic circuit involving Calb1+ neurons and Pomc+ neurons that coordinates β-endorphin release with ejaculation in male mice.

The three-dimensional landscape of chromatin accessibility in Alzheimer's disease

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.

Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

Association between genes regulating neural pathways for quantitative traits of speech and language disorders

This study identifies 18 significant genetic loci associated with speech sound disorders through GWAS and finds polygenic risk scores linked to clinical severity.

Functional annotation of rare structural variation in the human brain

The paper functionally annotates rare structural variants in the human brain by integrating SV calling with RNA-seq data to assess their regulatory effects and prioritize pathogenic deletions.

Role of anterograde motor Kif5b in clathrin-coated vesicle uncoating and clathrin-mediated endocytosis

This study shows Kif5b interacts with clathrin heavy chain and facilitates CCV uncoating, linking anterograde transport to clathrin-mediated endocytosis.