The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis
Hima Bindu Durumutla, April M. Haller, Greta Noble, Ashok Daniel Prabakaran, Kevin McFarland, Hannah Latimer, Akanksha Rajput, Olukunle Akinborewa, Bahram Namjou‐Khales, David Y. Hui, Mattia Quattrocelli
This study identifies a human GR variant, rs6190, that increases cholesterol and atherosclerosis risk by enhancing GR activity in mice and human cells.
Journal of Clinical Investigation · Jul 1, 2025Peer-reviewedPhysiology