G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs
Sunipa Sarkar, Akash Chatterjee, Subhojit Paul, Asim Bisoi, Prosenjit Sen, Prashant Chandra Singh
This study shows that HCQ and CQ downregulate c-myc oncogene transcription via G4 stabilization, reducing tumor growth and enhancing chemotherapy in breast cancer models.
Journal of Biological Chemistry · Sep 23, 2025Peer-reviewedBiochemistry