Effects of Pathological Mutations on the Prion-Like Polymerisation of MyD88
Ailís O’Carroll, Brieuc Chauvin, James Brown, Ava Meagher, Joanne Coyle, Dominic J. B. Hunter, Akshay Bhumkhar, Thomas Ve, Boštjan Kobe, Emma Sierecki, Yann Gambin
This study investigates how pathological mutations affect the prion-like polymerization of MyD88, showing that these mutations block polymerization and alter oligomer stability.
bioRxiv · Jun 20, 2018 · PreprintMolecular Biology