Thomas Ve

The paper identifies chemical inhibitors of SpbK, an antiphage defense system in Bacillus subtilis, showing they promote phage dissemination and reveal mechanisms of inhibiting TIR-domain enzymes.

This study shows that 3'cADPR-induced SIR2 filament formation activates ThsA effectors in type I Thoeris systems across bacterial species.

The paper identifies a Ca2+-phosphate bridge that stabilizes protein complexes during HIV assembly through phospho-proteomics and structural analyses.

The paper determines cryo-EM structures of a plant TNL NLR, revealing its activation mechanism and NAD+ recognition, which informs engineering disease-resistant crops.

This study identifies chemical inhibitors that block a bacterial immune system, enhancing phage therapy efficacy against resistant strains.

This study analyzes the TIRome of Arabidopsis to design artificial TIR proteins and identify functional polymorphisms that influence cell death and metabolite production.

This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.

The paper identifies nicotinic acid mononucleotide (NaMN) as an allosteric inhibitor of SARM1 that promotes axonal protection by blocking NMN binding and stabilizing the inactive SARM1 conformation.

This study investigates how pathological mutations affect the prion-like polymerization of MyD88, showing that these mutations block polymerization and alter oligomer stability.