Yann Gambin

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

The paper develops a method to express and visualize eukaryotic proteins using cell-free systems and cryo-electron tomography, demonstrating its application to study ASC protein filaments and their interaction with ribosomes.

The paper uses single molecule techniques to show that different alpha-synuclein polymorphs have distinct growth mechanisms in seed amplification assays, with one polymorph showing increased secondary nucleation.

This study uses single molecule fluorescence spectroscopy to quantify nanocondensate formation, revealing faster and lower concentration-dependent phase separation of TDP-43 than previously observed by microscopy.

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

The paper uses single molecule spectroscopy to compare the seeding properties of α-synuclein oligomers and preformed fibrils in amplification assays, finding that fibrils dominate the response despite lower quantities.

This study identifies SARS-CoV-2 proteases NSP3 and NSP5 cleaving IRF3, NLRP12, and TAB1, which modulate inflammatory pathways, and explores implications for disease across species and potential reservoir hosts.

This study investigates how pathological mutations affect the prion-like polymerization of MyD88, showing that these mutations block polymerization and alter oligomer stability.

This study shows that the RHIM domain of M45 protein forms amyloid fibrils with RIPK1 and RIPK3, inhibiting necroptosis.