Author

Alan Leyk

University of Colorado Boulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Annette H. ErbseiD· 1 shared Ava M. Hickey· 1 shared Corey D TesdahliD· 1 shared Elizabeth H. Mead· 1 shared Ian R FlemingiD· 1 shared Jonathan P. HannaniD· 1 shared Joseph J. FalkeiD· 1 shared Joy R ArmendariziD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Annette H. ErbseORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγRBD Frequently Generate Affinity Increases

Elizabeth H. Mead, Kaeden C. Batz, Kuo-Hsien Shih, Ian R Fleming, Corey D Tesdahl, Lucas Lizardos, Joy R Armendariz, Jonathan P. Hannan, Ava M. Hickey, Alan Leyk, Annette H. Erbse, Joseph J. Falke

The paper investigates how mutations at the H-Ras:PI3KγRBD interface affect binding affinity, finding that some mutations increase affinity while others decrease it, suggesting intermediate native affinity.

Biochemistry · May 18, 2026Peer-reviewedBiochemistry