COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγRBD Frequently Generate Affinity Increases
Elizabeth H. Mead, Kaeden C. Batz, Kuo-Hsien Shih, Ian R Fleming, Corey D Tesdahl, Lucas Lizardos, Joy R Armendariz, Jonathan P. Hannan, Ava M. Hickey, Alan Leyk, Annette H. Erbse, Joseph J. Falke
The paper investigates how mutations at the H-Ras:PI3KγRBD interface affect binding affinity, finding that some mutations increase affinity while others decrease it, suggesting intermediate native affinity.
Biochemistry · May 18, 2026Peer-reviewedBiochemistry