BiochemistryBiochemistryPeer-reviewed
COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγRBD Frequently Generate Affinity Increases
Elizabeth H. Mead, Kaeden C. Batz, Kuo-Hsien Shih…·Joseph J. Falke
The paper investigates how mutations at the H-Ras:PI3KγRBD interface affect binding affinity, finding that some mutations increase affinity while others decrease it, suggesting intermediate native affinity.
DOI 10.1021/acs.biochem.5c00815