GDNF enemas improve epithelial and immune defects in both aganglionic and ganglionic colon of Hirschsprung mice
Nejia Lassoued, Jacob Trudel, Marie A Lefèvre, Alassane Gary, Zhiqiang Guo, Alexis Yero, Mohammad-Ali Jenabian, Rodolphe Soret, Nicolas Pilon
This study shows that GDNF enemas improve epithelial and immune defects in both aganglionic and ganglionic colon of Hirschsprung mice, reducing bacterial translocation and inflammation.
bioRxiv · Sep 1, 2026 · PreprintDevelopmental Biology