GDNF regenerates the missing enteric nervous system of Hirschsprung mice via non-canonical signaling in diverse subtypes of tissue-resident progenitors
Alassane Gary, Rodolphe Soret, Marie A. Lefevre, Nejia Lassoued, Ann Aspirot, Christophe C. Faure, Nicolas Pilon
This study shows GDNF regenerates the missing enteric nervous system in Hirschsprung mice through non-canonical signaling in tissue-resident progenitors, suggesting potential for broader therapeutic applications.
bioRxiv · May 23, 2025 · PreprintNeuroscience