Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to 1 CA1 by differential modulation of feedforward inhibitory circuits
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin Gerald Tehan, Miles Congreve, Pradeep J. Nathan, Alastair Brown, Jack R. Mellor
This study shows acetylcholine equally depresses excitatory inputs from entorhinal cortex and CA3 in CA1 but enhances overall activation by preferentially depressing feedforward inhibition from entorhinal cortex.
Nature Communications · Sep 16, 2021Peer-reviewedNeuroscience